Ectopic HCN4 Provides a Target Biomarker for the Genetic Spectrum of mTORopathies

Neuro Genetics
Mar 26, 2024

HCN4 provides a biomarker for the genetic spectrum of mTORopathies and may present a potential therapeutic target for seizure control in mTOR-related epilepsy.

Read More

Rapidly Evolving Pre- and Post-surgical Systemic Treatment of Melanoma

Am J Clin Dermatol
Mar 25, 2024

Melanoma therapeutics continues to advance with combination adjuvant approaches now investigating anti-PD1 with lymphocyte activation gene 3 (LAG3), T-cell immunoreceptor with Ig and ITIM domains (TIGIT), and individualized neoantigen therapies. How this progress will be integrated into the management of a unique patient to reduce recurrence, limit toxicity, and avoid over-treatment will dominate clinical research and patient care over the next decade.

Read More

Assessment of the Diagnostic Accuracy and Reliability of the HEART Score Calculated by Ambulance Nurses Versus Emergency Physicians

AENJ
Mar 22, 2024

The study shows a moderate interrater reliability and lower predictive accuracy of a HEART score calculated by Ambulance Nurse (AN) versus EP. AN underestimate the risk of patients with acute chest pain, with the largest discrepancies in the elements History and Risk factors. Reconsidering the cut-off values of the low-risk HEART category, as well as a carefully developed training program, will possibly lead to a higher interrater reliability of the HEART score and higher predictive accuracy used by AN.

Read More

Telehealth Privacy and Security Tips

Skyscape
Mar 29, 2024

Buzz, a HIPAA-complaint platform enables providers to conduct secure video conferences or calls with patients quickly, easily & seamlessly.

Read More

Efficacy and Safety of Fractional Microneedle Radiofrequency for Atrophic Acne Scars

Lasers Surg. Med.
Mar 19, 2024

FMR is a safe and effective treatment modality for improving facial atrophic acne scars, and the number of FMR treatment sessions and pulse width are associated with clinical efficacy.

Read More

Single-Cell Transcriptomic Analysis Deciphers Heterogenous Cancer Stem-Like Cells in Colorectal Cancer and Their Organ-Specific Metastasis

Gut
Mar 18, 2024

By using integrative scRNA-seq, spatial transcriptomic analysis and functional assays, authors have uncovered a stem-like cell cluster marked with PTPRO and ASCL2 as the metastatic culprit, whose subpopulations show further different liver or ovary organotropism.

Read More

Exploring the Interrelationships Between Physical Function, Functional Exercise Capacity, and Exercise Self-Efficacy in Persons Living with HIV

Clinical Nursing Research
Mar 12, 2024

While physical activity can mitigate the metabolic effects of HIV disease and HIV medications, many HIV-infected persons report low levels of physical activity.

Read More

Childhood-Onset Myopathy With Preserved Ambulation Caused by a Recurrent ADSSL1 Missense Variant

Neuro Genetics
Mar 08, 2024

This study expands the phenotypic spectrum and variability of ADSSL1 myopathy with unusual manifestations in this rare disorder. Because the variant c.781G>A (p.Asp261Asn) is the most common mutation among Indian patients similar to other Asian cohorts, this finding could be useful for genetic screening of suspected patients.

Read More

Transcatheter or Surgical Aortic Valve Replacement in Patients With Severe Aortic Stenosis and Small Aortic Annulus

Circulation
Mar 07, 2024

In patients with severe aortic stenosis and SAA (women in the majority), there was no evidence of superiority of contemporary TAVR versus SAVR in valve hemodynamic results. After a median follow-up of 2 years, there were no differences in clinical outcomes between groups. These findings suggest that the 2 therapies represent a valid alternative for treating patients with severe aortic stenosis and SAA, and treatment selection should likely be individualized according to baseline characteristics, additional anatomical risk factors, and patient preference.

Read More

Human Hair Graying Revisited

JID
Mar 06, 2024

The temporary reversibility of graying is highlighted by several drugs and hormones that induce repigmentation, indicating potential target pathways. Authors advise caution in directly applying mouse model concepts, define major open questions, and discuss future human antigraying strategies.

Read More

Breastfeeding Characteristics and Duration of Feeding Human Milk in Infants With Congenital Heart Disease

JPNN
Mar 05, 2024

Future efforts to support feeding human milk in infants with CHD should emphasize practices that support maximal human milk production.

Read More