The Medical Letter’s Database of Adverse Drug Interactions now Available on PDA

THE MEDICAL LETTER’S DATABASE OF ADVERSE DRUG INTERACTIONS NOW AVAILABLE ON PDA

Medical Letter Signs Licensing Agreement with Skyscape for DrugIx™

New Rochelle, NY – October 29, 2002 - The Medical Letter® has signed an agreement with Skyscape, Inc., to make the Medical Letter’s highly regarded Adverse Drug Interactions database, based on its Handbook of Adverse Drug Interactions, available on personal data assistants (PDAs) running the Palm OS® and Windows CE®/Pocket PC operating systems. The new software called DrugIx® is available for handheld devices from Skyscape and gives the medical community convenient access to interactions between as many as 16 drugs with Palm OS® or an unlimited number of drugs with Pocket PC.

“DrugIx™ provides physicians with rapid access to a highly regarded drug interaction database and will help them to prescribe appropriate nonconflicting drugs, right at the point of patient care,” said Gianna Zuccotti, M.D., M.P.H., Deputy Editor of The Medical Letter. “The new software also expands our family of medical information resources for the handheld, giving physicians greater choices in how they receive information.”

Unlike other drug interaction databases, The Medical Letter’s evidence-based database is clinically oriented and well documented, and generally does not contain theoretical interactions unless they are considered contraindications by the FDA. The resulting report differs from a pharmacy-derived report in that it contains only interactions that have been shown to be clinically significant. The report describes the interaction and its probable mechanism and offers recommendations for clinical management and references to the original reports. The database is updated and the software re-released every six months. It is also available as a handbook, published annually, and a CD-ROM program.

“We work with the world’s leading medical publishers, using our technology to create handheld versions of the best medical references,” said Sandeep Shah, president and CEO of Skyscape. “We expect DrugIx to gain the same tremendous acceptance among the medical community as our other solutions because of the quality of the content provided by The Medical Letter and our ability to give users not just the information they need, but the capability to use it the way they think.”

DrugIx is a valuable resource for the growing number of physicians who use a PDA in their clinical practices. For details about DrugIx, visit the Skyscape Web site by clicking the link on The Medical Letter Web site: www.medicalletter.org and click on Products> Software> Adverse Drug Interactions> PDA, or go directly to the Skyscape Web site at www.skyscape.com. Medical Letter subscribers receive a ten percent discount as an introductory offer.

About Skyscape

Skyscape is the leading provider of interactive, intelligent mobile solutions for the healthcare community. Skyscape utilizes its patented ART (Advanced Reference and Transaction) infrastructure technology to create compelling high-value solutions for handheld devices that reflect and support the intuitive thought processes of the medical practitioner. Skyscape’s solutions significantly improve the quality and efficiency of medical decision making—at the point of care—by enabling doctors to diagnose illnesses, determine treatment, prescribe medication, identify drug interactions, calculate dosages and perform all the necessary steps involved with quality patient care.

Skyscape has the largest installed base of paying customers in the industry including individual and communities of medical practitioners at Harvard Medical School, Massachusetts General Hospital, Brigham and Women’s Hospital, Stanford Medical School, Partners Health System, Duke University, Mayo Clinic, and Kaiser Permanente. Skyscape’s solutions are available on multiple platforms including Palm OS®, Windows® CE, and Pocket PC. For more information about Skyscape, please visit our Web site at www.skyscape.com.

About The Medical Letter

The Medical Letter Inc., a nonprofit organization founded in 1958, offers health care professionals objective, independent analysis of new drugs. It publishes critical and unbiased evaluations of new drugs in its biweekly newsletter, The Medical Letter on Drugs and Therapeutics, as well as Treatment Guidelines from The Medical Letter, and handbooks and software on topics such as adverse drug interactions and antimicrobial therapy. The Medical Letter, Inc. is supported entirely by subscriber fees and is based in New Rochelle, NY. For more information about The Medical Letter call (800) 211-2769 or visit its Web site at www.medicalletter.org.